|Stage of cancer||Five-year survival rate percentage (%)|
The 5-year survival rate for a patient with Paget disease and sarcoma is 5-7.5%; however, it may be as high as 50% for those who undergo operative tumor ablation and chemotherapy before metastases occur. The 5-year survival rate for elderly patients with primary nonpagetic sarcoma is 37%.
Paget disease can be treated by removing the entire breast (mastectomy) or breast-conserving surgery (BCS) followed by whole-breast radiation therapy. If BCS is done, the entire nipple and areola area also needs to be removed. If invasive cancer is found, the lymph nodes under the arm will be checked for cancer.
As a noninvasive form of cancer, Paget’s is not considered an aggressive or fast-moving disease, but it is often associated with another cancer in the same breast.
The cause of Paget’s disease of bone is unknown. Scientists suspect a combination of environmental and genetic factors contribute to the disease. Several genes appear to be linked to getting the disease.
Paget’s disease can affect bone growth in the skull or spine, causing pressure on a nerve. Also, Paget’s disease can damage the tiny bones in the ear, leading to hearing loss. Paget’s disease can cause nerve problems such as: Hearing loss or ringing in the ears (tinnitus).
Most women with Paget’s disease of the breast have an underlying malignancy, which may be completely contained within the milk ducts (ductal carcinoma in situ) or may have invaded the surrounding tissue, potentially spreading to the lymph nodes under the arms (axillary lymph nodes) and other regions of the body ( …
Three phases of Paget disease have been described: lytic, mixed lytic and blastic, and sclerotic. In an individual patient, different skeletal lesions may progress at different rates. Thus, at any one time, multiple stages of the disease may be demonstrated in different skeletal regions.
Unless the physician is familiar with the disease, they do not know what to look for. It does not show up on a typical mammogram or ultrasound. It took a breast MRI with contrast for my Paget’s and DCIS to show up. Paget’s is almost always accompanied by a secondary underlying breast cancer.
Mammography. Mammography plays an important role in the diagnosis and management of Paget’s disease; however, it has its own limitations and may be normal in some cases (Fig. 2). The common mammographic findings are skin thickening in the nipple areolar region (Fig.
- Flaky or scaly skin on your nipple.
- Crusty, oozing or hardened skin resembling eczema on the nipple, areola or both.
- A tingling or burning sensation.
- Straw-colored or bloody nipple discharge.
- A flattened or turned-in (inverted) nipple.
Paget’s disease causes the skin on and around the nipple to become red, sore, and flaky, or scaly. At first, these symptoms tend to come and go. Over time, symptoms of Paget’s disease usually worsen and may include: itching, tingling, and/or a burning sensation.
This disease may at first. look like eczema of the nipple Eczema should respond to simple treatment with corticosteroid creams. If a rash on the nipple does not disappear with such treatment, then Paget’s disease is suspected.
Bone pain. Bone pain caused by Paget’s disease is usually: dull or aching. deep within the affected part of the body.
When Paget’s disease is active in several bones, the overactive osteoclasts can release enough calcium from the bone as they break it down to cause an elevated calcium level in the blood. This rare complication might cause fatigue, weakness, loss of appetite, abdominal pain, or constipation.
Paget’s disease of the nipple is more common in women, but like other forms of breast cancer, it can also affect men. The disease usually develops after age 50. According to the National Cancer Institute, the average age of diagnosis in women is 62, and in men, 69.
Heart failure. Bone tissue contains many blood vessels. Paget’s disease causes increased blood flow to the bones, and sometimes it is difficult for the heart to keep up with the demand for increased blood flow. This can lead to heart failure.
Paget’s disease is an uncommon disorder that leads to abnormal bone development. Your jawbones will be affected, and this can cause mild or severe dental health issues such as tooth loss, jaw fractures, and bite alignment. Furthermore, there are times when jawbone deformities might occur.
Paget disease of the breast occurs in both women and men, but most cases occur in women. Approximately 1 to 4 percent of all cases of breast cancer also involve Paget disease of the breast. The average age at diagnosis is 57 years, but the disease has been found in adolescents and in people in their late 80s (2, 3).
How common is Paget’s disease of the breast? Paget’s disease makes up about 1-4% of breast cancers. It develops in both women and men, but happens more in women. It most commonly occurs in women over 50 years old.
Bisphosphonates are first-line therapy for Paget’s disease, and the advent of the new bisphosphonates permits a dramatic improvement in treatment.
Paget’s disease of the nipple always starts in the nipple and may extend to the areola. It appears as a red, scaly rash on the skin of the nipple and areola. The affected skin is often sore and inflamed, and it can be itchy or cause a burning sensation. The nipple can sometimes be ulcerated.
There are several causes of nipple or areola dermatitis. These include eczema and irritation or allergic dermatitis. Certain types of dermatitis can also cause eczema. Eczema is a common condition in breast-feeding women, especially those who have previously been affected by atopic dermatitis.
Paget disease of the breast is often mistaken for eczema. Eczema is an itchy, red skin rash. It is not cancer. Although Paget disease and eczema can look alike, Paget disease most often affects only one nipple and doesn’t go away after using common eczema treatments.